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- Berg, E
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| About Stephen Bryant (NIH) |
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As a Senior Investigator in NCBI’s Computational Biology Branch, Dr. Bryant focuses his research team’s effort on structural bioinformatics and related areas. Dr. Bryant also directs NCBI information resource teams in protein structure, protein family classification, and cheminformatics. These teams maintain NCBI’s macromolecular structure database and Cn3D visualization tool, the Conserved Domain Database and CDTree analysis tool, and most recently the PubChem cheminformatics database and associated data-analysis tools.
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Toxicology Data Sets in PubChem
Stephen Bryant (Senior Investigator, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health)
PubChem is an online public information resource from the National Center for Biotechnology Information (NCBI). The system provides information on the biological activities of chemical substances, linking results on the basis of chemical structure and observed bioactivities. Following the deposition model introduced by GenBank, PubChem content is derived from contributor uploads of chemical structure and bioassay data, including high-throughput biological screening results from the NIH Molecular Libraries program. PubChem also includes many bioassays with the results of toxicology experiments. PubChem information retrieval provides basic search results as well as structure-activity analysis within and between such bioassays. In this talk I’ll describe some of the toxicology bioassays in PubChem, illustrating the search and data analysis tools PubChem currently provides.
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