|
|
|
|
|
|
|
|
Applying the Latest Advances in Molecular Science
to the Development of new Medical Medicines and Solutions |
InterAction Meeting Session, held in Philadelphia, USA, 11 October 2005
Protein Folding, Misfolding & Aggregation: Applications to Disease
chaired by Nikolay V. Dokholyan (University of North Carolina)
| Presenters & Discussion Leaders:
Amyloid beta-protein oligomerization and Alzheimer’s disease, David Teplow (David Geffen School of Medicine at UCLA)
Direct observation of protein folding, misfolding and prion-like conformational infectivity, Feng Ding (University of North Carolina)
Catalytic origins of protein misfolding in end-stage renal failure, Andrew Miranker (Yale University)
Detection of Intermediate States of Cell Adhesion Proteins Using Discrete Molecular Dynamics (DMD) Simulations Constrained By Nuclear Magnetic Resonance (NMR) Hydrogen Exchange (HX) Data, Richard Dixon (University of North Carolina)
Approaches to medicine are rapidly changing as we begin to comprehend human disease at the most fundamental molecular level. Much of this change is heralded by a more quantitative and mechanistic understanding of the alterations of molecular structure and dynamics that produce disease. Recent years have brought a dramatic increase in the number of known associations between human disease and abnormalities in protein dynamics and structure. In particular, the number of diseases known to be associated with protein aggregation has increased several-fold. Since protein structure and dynamics are intimately related to protein cellular function, abnormalities in protein folding dynamics and structural stability often adversely affect cell life. Understanding protein folding, misfolding and aggregation will be vital to understanding human diseases, ranging from various forms of cancer to neurodegenerative diseases, and will facilitate the development of therapeutic strategies to combat these diseases.
The focus of the "Protein Folding, Misfolding & Aggregation: Applications to Disease" symposium is to bring together world-class researchers working on both theoretical and experimental fronts of the protein folding field, and have them present recent cutting-edge research results. The emphasis of the symposium is on communication and open discussion, which we hope will lead to new ideas and collaborations.
| |
|
|
|
|
|
|
|
