|
|
|
|
|
|
The Autumn 2008 InnovationWell community of practice meeting will take place 14-17 October 2008 at Bryn Mawr College and will discuss themes related to systems biology, metabolomics, toxicology, computational biology, translational medicine, ADME and knowledge management. The 2007 program is described below. More Information on 2008 Program....
|
|
Program and Schedule
| | InterAction Meeting at Bryn Mawr, Philadelphia (15-19 October 2007) | Program Agenda and Schedule
MONDAY 15 OCTOBER
07.30 Registration & Welcome Coffee Opens, Thomas Great Hall
InnovationWell Workshop on Knowledge Management in R&D, 09.00 – 18.30 [Thomas Great Hall]
More Information on Workshop....
18.30 Networking Garden Reception, Bryn Mawr College, Alumni House
19.30 Knowledge Dinner, Bryn Mawr College Alumni House
TUESDAY 16 OCTOBER
InnovationWell Workshop on Knowledge Management in R&D, 09.00 – 18.00 [Thomas Great Hall]
18.00 Poster Session, Drinks & Dinner [Thomas Great Hall]
WEDNESDAY 17 OCTOBER
InnovationWell InterAction Meeting Session, 09.00 – 18.00 [Thomas 224]
Systems-based Toxicology
Salvatore Alesci (Wyeth Research), Biomarker Discovery, Validation and Implementation in Translational Medicine
Laszlo G. Boros (SIDMAP), Determination of new Biomarkers for Liver Toxicity in the form of Stabile Isotope Labeled Metabolites
Richard Beger (FDA), Metabonomics of Acute Renal Failure in Children during Cardiopulmonary Bypass Surgery
Darius M. Dziuda (Central Connecticut State University), Multivariate Approach to The Informative Set of Genes
Fred Cohen (Fast Track Systems), Structured Knowledge Transfer and Integration of Preclinical Biomarker Data for Decision Making in Drug Development
Alex Tropsha (University of North Carolina), The Use of Cell Viability High Throughput Screening Data as Additional Biological Descriptors Improves the Prediction Accuracy of Conventional Quantitative Structure Activity Relationship Models of Chemical Toxicity
18.00 Poster Session, Drinks and Dinner [Thomas Great Hall]
THURSDAY 18 OCTOBER
InterAction Meeting Session, 08.30 – 13.00 [Thomas 110]
Predictive ADME/Toxicology
Chair: Tony Hopfinger (University of New Mexico College of Pharmacy)
More Information on Session including Abstracts and Biographies....
08.30 Chair’s Introduction & Opening Remarks
08.45 Joseph Tomaszewski (NCI), Predictive ADMET at the NCI
09.20 Artem Cherkasov (University of British Columbia), Drugs, Drug-Likeness, Metabolism, Antimicrobals
09.55 Dennis Pelletier (Pfizer), Predicting Phospholipidosis Inducing Potential
10.30 Coffee Break
11.00 Richard Beger (FDA), Comparison of TEFs and REPs Predicted by Quantitative Spectrometric Data-Activity Relationships and REPs Determined by a Luciferase Gene Expression Assay for 1,3,7,8-TCDD and 1,2,3,4,7-PeCDD
11.35 Anthony Klon (Pharmacopeia Drug Discovery), Bayesian Modeling of Numerical Data for ADME Property Prediction
12.10 Panel Discussion
13.00 Lunch
Predictive ADME/Toxicology Forum and Workshop Activity, 14.00-18.00 [Thomas Great Hall]
This workshop will include discussion of the following topics:
* latest advances in QSAR and ADME/Tox methodologies and resources
* impact of government and regulatory policy and legislation in the US and Europe
* potential and barriers for replacing animal testing by alternative approaches
* actions for data integration and knowledge sharing between initiatives
* the role of semantic web approaches in uniting structured data from multiple resources
* the role of natural language processing for processing unstructured information
* extraction of data from the scientific literature
* application of advanced search and agent technologies
18.00 Poster Session, Drinks and Dinner [Thomas Great Hall]
FRIDAY 19 OCTOBER
InterAction Meeting Session, 08.30 – 13.00 [Thomas 110]
Predictive ADME/Toxicology
Chair: Tony Hopfinger (University of New Mexico College of Pharmacy)
More Information on Session including Abstracts and Biographies....
08.30 Tony Hopfinger (University of New Mexico College of Pharmacy), ADME/Tox Modeling From Informatics to Structure-Based Paradigms
09.00 Joseph Contrera (FDA), QSAR screening for carcinogenic potential using multiple models and software platforms
09.30 Christoph Helma (University of Freiburg and in silico toxicology) In-silico prediction of chemical toxicity: Lazy-Structure-Activity-Relationships (lazar) and the OpenTox framework
10.00 Vladimir Poroikov (Russian Academy of Sciences), Bio- and Chemoinformatics Applications in Discovery of Multitargeted Drugs
10.30 Coffee Break
11.00 Judith Madden (Liverpool John Moores University), Application of Global and Local In Silico Models to Predict Pharmacokinetic Properties
11.30 Ann Richard (EPA), Toxico-Cheminformatics in Support of Predictive Toxicology
12.00 Eric Jamois (Strand Life Sciences), Towards Cognizant Data Models for SAR and Modelling of ADME/Tox Properties
12.30 Panel Discussion
13.00 Lunch
Predictive ADME/Toxicology Forum and Workshop Activity, 14.00-16.00 [Thomas Great Hall]
This workshop will include discussion of the following topics:
* methods and procedures for secure testing of commercial data that could be acceptable to industry
* frameworks for computational model testing and validation
* impact of knowledge management approaches
* collaboration and community support structures and environments
16.00 Close of Program
|
|
|
|
|
|
|
|
|
|
